Melittin-grafted HPMA-oligolysine based copolymers for gene delivery
نویسندگان
چکیده
منابع مشابه
Comparative study of guanidine-based and lysine-based brush copolymers for plasmid delivery.
Polyethylenimine (PEI), one of the most frequently used polycations for non-viral nucleic acid delivery, exhibits good transfection efficiency to cultured cells but generally has to be used in restricted concentration ranges due to high cytotoxicity. We recently reported a family of HPMA-co-oligolysine brush copolymers that show nucleic acid delivery efficiencies approaching that of PEI. Guanid...
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ژورنال
عنوان ژورنال: Biomaterials
سال: 2013
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2012.09.072